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Title 

Nucleophilic substitution reactions of 4,5-dichloro-2-methyl-6-nitro-2H-pyridazin-3-one

Authors 

Kyu Tae ChangJeum Jong KimYoung Kook KimHo Yong ParkByung Hwa HyunMotoo ShiroYong Jin YoonWoo Song Lee

Publisher 

Elsevier

Issue Date 

2001

Citation 

Heterocycles, vol. 55, no. 10, pp. 1927-1935

Keywords 

N-acyclonucleosidephenoxylationpyridazineselectivity on pyridazine4 chloro 2 methyl 5 (4 nitrophenoxy) 6 nitro 2h pyridazin 3 one4 chloro 2 methyl 6 nitro 5 phenoxy 2h pyridazin 3 one4 chloro 5 (2 mercaptopyrimidyl) 2 methyl 6 nitro 2h pyridazin 3 one4 chloro 5 (4 chlorophenoxy) 2 methyl 6 nitro 2h pyridazin 3 one4 chloro 5 (4 cyanophenoxy) 2 methyl 6 nitro 2h pyridazin 3 one5 chloro 2 methyl 4 (4 nitrophenoxy) 6 nitro 2h pyridazin 3 one

Abstract 

4,5-Dichloro-2-methyl-6-nitro-2H-pyridazin-3-one (1) reacts with various substituted phenols and 2-mercaptopyrimidine in the presence of NaH or K2CO3 to give 3(2H)-pyridazinones (4, 5a-9a, 5b-9b, and 7c) in high yields. The regiochemistry was confirmed by X-Ray analysis and nOe experiments.

ISSN 

0385-5414

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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