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Title 

Combretoxazolones : synthesis, cytotoxicity and antitumor activity

Authors 

Nguyen-Hai NamYong KimYoung Jae YouDong Ho HongHwan Mook KimByung Zun Ahn

Publisher 

Elsevier

Issue Date 

2001

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 11, no. 23, pp. 3073-3076

Keywords 

antineoplastic activitycytotoxicitydrug activitydrug synthesisdrug screening assays, antitumor

Abstract 

Two series of combretoxazolones including 3,4-diaryloxazolones (6) and 4,5-diaryloxazolones (7) were synthesized and evaluated for cytotoxicity and antitumor activity. Both series showed strong cytotoxicities against a variety of tumor cell lines. Compound 6g exhibited a significant antitumor activity in BDF1 mice bearing B16 murine melanoma cells with inhibition rates of 67 and 61% at 100 and 30 mg/kg/day, respectively.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/S0960-894X(01)00622-9

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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