상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Enhanced IL-18 expression in common skin tumors

Authors 

Hyun Jeong ParkDae Yoo ByunTae S KimYoung I KimJae S KangEun S HahmSeong H KimWang J LeeHyun Keun SongDo Young YoonChang J KangChnag Nam LeeDong HouhHyung Ok KimBaik Kee ChoYoung Sill KimYool H YangKyung H MinDae H Cho

Publisher 

Elsevier

Issue Date 

2001

Citation 

Immunology Letters, vol. 79, no. 3, pp. 215-219

Keywords 

IL-18skin tumorssquamous cell carcinomainterleukin 18protein expressionskin tumorgene expression regulation, neoplasticinterleukin-18killer cells, naturalskin neoplasms

Abstract 

Interleukin-18 (IL-18) has been found to have multiple effects upon various cells involved in inflammatory response. Recently we reported that B16 murine melanoma cells are able to produce IL-18, which is involved in the regulation of intracellular reactive oxygen intermediates (ROI) and Fas-ligand expression, indicating that IL-18 plays key role in the tumor activity of melanoma. In this study, we investigated the pattern of IL-18 expression in the human system. IL-18 production was tested by enzyme linked immunosorbent assay (ELISA) assay in various tumor cell lines, including Raji (Burkett's lymphoma), IM-9 (B lymphoblast), Jurkat (acute T cell leukemia), SK-MES-1 (squamous cell carcinoma (SCC) cell line), SK-MEL-2, G-361, DM-4, and DX-3 (melanoma cell lines). ELISA tests showed that IL-18 was highly expressed in malignant skin tumors such as SK-MES-1, SK-MEL-2, G-361, DM-4, and DX-3 cell lines, thus suggesting that IL-18 production may be associated with the malignancy of skin tumors. Here, we report that enhanced IL-18 expression is positively correlated with malignant skin tumors such as SCC and melanoma, suggesting the importance role of IL-18 in malignancy of skin tumors. Taken together, expression of IL-18 by tumor cells in human skin tissue may provide an important clue to understand the pathogenesis of malignant skin tumors.

ISSN 

0165-2478

Link 

http://dx.doi.org/10.1016/S0165-2478(01)00278-4

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)