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Title 

5,6-Diphenylpyridazine derivatives as acyl-CoA : cholesterol acyltransferase inhibitors

Authors 

Maria Palola GiovannoniVittorio Dal PiazByoung-Mog KwonMi Kyung KimYoung Kook KimLucio TomaDaniela BarloccoFranco BerniniMonica Canavesi

Publisher 

American Chemical Society

Issue Date 

2001

Citation 

Journal of Medicinal Chemistry, vol. 44, no. 24, pp. 4292-4295

Keywords 

5,6 diphenylpyridazine derivativecholesterol acyltransferase inhibitorenzyme inhibitorssterol o-acyltransferase

Abstract 

Alkyl-5, 6-diphenylpyridazine derivatives combining several main features of ACAT inhibitors, such as a long alkyl side chain linked to a heterocycle and the o-diphenyl system, were synthesized and tested. Moreover, modeling studies on representative terms were performed. Some compounds displayed ACAT inhibition in the micromolar range, both on the enzyme isolated from rat liver microsomes and in cell-free homogenate of murine macrophages.

ISSN 

0022-2623

Link 

http://dx.doi.org/10.1021/jm010807h

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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