상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Genetic factors associated with endothelial dysfunction affect the early onset of coronary artery disease in Korean males

Authors 

Won Ha LeeTae Hong HwangGoo Taeg OhSung Uk KwonYoon Ho ChoiJeong Euy Park

Publisher 

SAGE Publications (UK and US)

Issue Date 

2001

Citation 

Vascular Medicine, vol. 6, no. 2, pp. 103-108

Keywords 

coronary artery diseaseendothelial dysfunctionnitric oxidedisease associationdisease coursegenetic associationgenetic polymorphismmaleonset age

Abstract 

The maintenance of balance between nitric oxide (NO) and the superoxide anion is required for proper functioning of the endothelium. To investigate the relationship between genetic factors associated with endothelial function and the development of coronary artery disease (CAD), endothelial nitric oxide synthase (ecNOS) gene a/b polymorphism and NADH/NADPH oxidase p22 phox gene C242T polymorphism were examined in 305 Korean male CAD patients and 215 healthy male control subjects. The β-fibrinogen gene H1/H2 polymorphism was also analyzed. Both ecNOS a/b and p22 phox C242T polymorphisms were found to be associated with the development of CAD in the study population (p = 0.020 and 0.011, respectively). When the association was analyzed by age, statistical significance was retained only in those <51 years (p = 0.021 and 0.025 for the a/b and the C242T polymorphism, respectively) and not in those >51 years of age (p = 0.155 and 0.278 respectively). However, the distribution of the β-fibrinogen H1/H2 genotypes was not found to be associated with the development of CAD in either the ≤50 (p = 0.611) or >50 groups (p = 0.188). The ecNOS gene a/b polymorphism and the NADH/NADPH oxidase p22 phox gene C242T polymorphism were found to be significantly associated with the development of CAD in Korean male patients less than 51 years old.

ISSN 

1358-863X

Link 

http://dx.doi.org/10.1191/135886301680223635

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)