상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Enhanced susceptibility to Theiler's virus-induced demyelinating disease in perforin-deficient mice

Authors 

Joann P PalmaHee Gu LeeMani MohindruBong Su KangMauro Dal CantoStephen D MillerByung S Kim

Publisher 

Elsevier

Issue Date 

2001

Citation 

Journal of Neuroimmunology, vol. 116, no. 2, pp. 125-135

Keywords 

CTLinfectious immunityneuroimmunologyvirusperforinanimal tissuecontrolled studydemyelinating diseasedisease coursedisease predisposition

Abstract 

Theiler's virus induces immune-mediated demyelinating disease similar to human MS in susceptible mice. Though the MHC class II-restricted T cell response is critical, susceptibility/resistance is also associated with a MHC class I haplotype. Here we report that perforin-deficient C57BL/6 mice (pKO) are susceptible to demyelination and develop clinical disease. The levels of primary demyelination, proliferation, Th1 responses, and viral load were also markedly enhanced. In addition, immunization of pKO mice with UV-inactivated virus further enhanced clinical incidence and accelerated the disease course. Thus, perforin is most likely involved in viral clearance, hence protection from the disease.

ISSN 

0165-5728

Link 

http://dx.doi.org/10.1016/S0165-5728(01)00293-4

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)