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Title 

A New guaianolide as apoptosis inhibitor from Chrysanthemum boreale

Authors 

Jong Rok LeeMin Suk YangDae Sik JangTae Joung HaKi Min ParkChoong Hwan LeeYung Hee KhoKi Hun Park

Publisher 

Georg Thieme Verlag

Issue Date 

2001

Citation 

Planta Medica, vol. 67, no. 6, pp. 585-587

Keywords 

8 o acetyl 3,10 dihydroxy 4(15),11(13)guaiadien 12,6 olideapoptosis inhibitorchrysanthemum boreale extractguaianolide derivativeunclassified drugapoptosischrysanthemumdrug activitydrug isolationhuman

Abstract 

The 8-O-acetyl-3,10-dihydroxy-4(15),11(13)-guaiadien-12,6-olide, named borenolide, was isolated from Chrysanthemum boreale M. Borenolide inhibits the etoposide-induced apoptosis in U937 cell with an IC50 value of 6.2 μg/ml. Structural assignment was based on NMR-spectroscopic methods and X-ray crystallographic analysis.

ISSN 

0032-0943

Link 

http://dx.doi.org/10.1055/s-2001-16477

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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