상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Lipid-lowering and antioxidative activities of 3,4-di(OH)-cinnamate and 3,4-di(OH)-hydrocinnamate in cholesterol-fed rats

Authors 

Jeong Sun LeeMyung Sook ChoiSeon Min JeonTae Sook JeongYong Bok ParkMi Kyung LeeSong Hae Bok

Publisher 

Elsevier

Issue Date 

2001

Citation 

Clinica Chimica Acta, vol. 314, no. 1, pp. 221-229

Keywords 

3,4-di(OH)-cinnamate3,4-di(OH)-hydrocinnamateantioxidant enzymescholesterol metabolismfecal sterolsHMG-CoA reductasecholesterolcholesterol acyltransferase3,4 di(OH) cinnamatelipid

Abstract 

Background: Polyphenols appear to have antioxidant activities and may mediate lipid lowering. Methods: Four groups of rats, a high-cholesterol control (HC), HC + lovastatin, HC + 3,4-di(OH)-cinnamate, and HC + 3,4-di(OH)-hydrocinnamate, were given a semi-synthetic diet. The cinnamate derivative or lovastatin (0.1 g/100 g) supplements were given for 6 weeks. Results: The plasma total cholesterol concentration was significantly lowered by the 3,4-di(OH)-cinnamate supplement compared to the control or lovastatin group. The 3,4-di(OH)-cinnamate and 3,4-di(OH)-hydrocinnamate supplements significantly lowered both the hepatic cholesterol and triglyceride levels, while lovastatin only lowered the hepatic cholesterol. The hepatic HMG-CoA reductase activities were significantly lower in the 3,4-di(OH)-cinnamate and 3,4-di(OH)-hydrocinnamate groups than in the control or lovastatin group. The ACAT activity was only significantly lower in the lovastatin group compared to the other groups. With regards the hepatic antioxidant enzyme system, the CAT activity was significantly higher in the 3,4-di(OH)-cinnamate and 3,4-di(OH)-hydrocinnamate groups compared to the control or lovastatin group. The two cinnamate derivatives resulted in an increased hepatic GSH-Px activity. Meanwhile, all the supplements significantly lowered the hepatic thiobarbituric acid reactive substances (TBARS) content. However, the 3,4-di(OH)-cinnamate and 3,4-di(OH)-hydrocinnamate supplements did not alter the neutral sterol and total fecal sterol. Conclusions: Both cinnamate derivatives were potent in lipid-lowering and altering the antioxidative enzyme. Furthermore, these results also suggest that 3,4-di(OH)-cinnamate is more effective than 3,4-di(OH)-hydrocinnamate in its lipid-lowering action.

ISSN 

0009-8981

Link 

http://dx.doi.org/10.1016/S0009-8981(01)00700-8

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)