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Title 

Targeted gene disruption of the avermectin B O-methyltransferase gene in Streptomyces avermitilis

Authors 

Young Soo HongJeong Hyung LeeHang Sub KimKyu Won KimJung Joon Lee

Publisher 

Springer Verlag (Germany)

Issue Date 

2001

Citation 

Biotechnology Letters, vol. 23, no. 21, pp. 1765-1770

Keywords 

avermectinavermectin O-methyltransferasegene disruptionabamectinavermectin aavermectin b o methyltransferaseavermectin derivativemethyltransferasebacterial geneticsgene function

Abstract 

The biological activity of avermectin B components is superior to that of avermectin A components, which are derived from avermectin B by avermectin B 5-O-methyltransferase. Gene disruption, targeting avermectin B 5-O-methyltransferase gene in Streptomyces avermitilis, was carried out to obtain a strain of avermectin B producer. Phenotype analysis of the mutant with the disrupted O-methyltransferase gene showed that only avermectin B components were produced with a significant increase in production.

ISSN 

0141-5492

Link 

http://dx.doi.org/10.1023/A:1012496317299

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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