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Title 

Molecular cloning and characterization of the doxA cytochrome P-450 hydroxylase gene in Streptomyces peucetius subsp. caesius ATCC 27952

Authors 

Young Soo HongHang Sub KimJeong Hyung LeeKyu Won KimJung Joon Lee

Publisher 

The Korean Society for Applied Microbiology

Issue Date 

2001

Citation 

Journal of Microbiology and Biotechnology, vol. 11, no. 5, pp. 895-898

Keywords 

caesiuscytochrome P-450DoxAhydroxylasestreptomyces peucetius subspcytochrome P450peptidebacterial genegene expressiongenetic analysis

Abstract 

DNA sequence analysis of doxA from Streptomyces peucetius subsp. caesius ATCC 27952 revealed a 95% amino acid identity with that of Streptomyces strain C5. DoxA from S. peucetius subsp. caesius ATCC 27952 encodes a peptide with both conserved heme-binding and dioxygen-binding motifs. Expression of this gene in S. lividans 1326 resulted in bioconversion of daunorubicin to doxorubicin.

ISSN 

1017-7825

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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