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Title 

Pleckstrin homology domain interacts with Rkp1/Cpc2, a RACK1 homolog, to modulate Pck2-mediated signaling process in Schizosaccharomyces pombe

Authors 

Mi Sun WonYoung Joo JangKyung Sook ChungDong Uk KimKwang Lae HoeMi Young HanHyung Bae KimSang Hee LeeHyun Wha OhHyang Sook Yoo

Publisher 

Elsevier

Issue Date 

2001

Citation 

Biochemical and Biophysical Research Communications, vol. 289, no. 5, pp. 987-992

Keywords 

fission yeastpleckstrin homology domainRACK1Rkp1/Cpc2fungal proteinpleckstrinprotein cpc2protein pck2protein rack1protein rkp1

Abstract 

Rkp1/Cpc2, a fission yeast RACK1 homolog, interacts with Pck2, a PKC homolog, and is involved in the regulation of pck2-mediated signaling process. The N-terminal region of split pleckstrin homology domain (nPH) in human PLC-γ1 bound to Rkp1/Cpc2 concomitantly with Pck2. nPH inhibited kinase activity of GST-Pck2 purified from Schizosaccharomyces pombe in vitro. The lethality induced by pck2+ overexpression was suppressed by coexpression of either rkp1+ or nPH domain. This result suggests that Rkp1/Cpc2 interacts with PH domain-containing protein and regulates the Pck2-mediated signaling process in S. pombe.

ISSN 

0006-291X

Link 

http://dx.doi.org/10.1006/bbrc.2001.6094

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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