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Title 

5-demethylovalicin, as a methionine aminopeptidase-2 inhibitor produced by Chrysosporium

Authors 

Kwang Hee SonJu Young KwonHa Won JeongHyae Kyeong KimChang Jin KimYi Hwa ChangJung Do ChoiByoung-Mog Kwon

Publisher 

Elsevier

Issue Date 

2002

Citation 

Bioorganic & Medicinal Chemistry, vol. 10, no. 1, pp. 185-188

Keywords 

5 demethylovalicinenzyme inhibitormethionine aminopeptidase 2methionine aminopeptidase 2 inhibitorunclassified drugangiogenesisantineoplastic activitychrysosporiumdrug isolationhuman

Abstract 

5-Demethylovalicin, isolated from the fermentation broth Chrysosporium inhibited the recombinant human MetAP-2 (IC50=17.7 nM) and the growth of human umbilical vein endothelial cells (HUVEC; IC50=100 nM) in cell proliferation assay without cytotoxicity on the transformed cell lines.

ISSN 

0968-0896

Link 

http://dx.doi.org/10.1016/S0968-0896(01)00268-1

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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