상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Neuroprotectins A and B, bicyclohexapeptides protecting chick telencephalic neuronal cells from excitotoxicity I : fermentation, isolation, physico-chemical properties and biological activity

Authors 

Hiroyuki KobayashiKazuo Shin-yaKoji NagaiKen-ichi SuzukiYoichi HayakawaHaruo SetoBong Sik YunIn Ja RyooJung Sik KimChang Jin KimIck Dong Yoo

Publisher 

Nature Publishing Group

Issue Date 

2001

Citation 

Journal of Antibiotics, vol. 54, no. 12, pp. 1013-1018

Keywords 

bicyclo compoundcomplestatinexcitatory amino acidglutamic acidhexapeptidekainic acidneuroprotectin aneuroprotectin bneuroprotective agentneurotoxin

Abstract 

Glutamate, an excitatory amino acid, is known to induce neurotoxicity in central nervous system under abnormal conditions such as ischemia, hypoglycemia, epilepsy, Huntington's chorea, Parkinson's disease and Alzheimer's disease. In our search for neuroprotective agents of microbial origin against excitatory neurotoxins, we have isolated two new bicyclohexapeptides, neuroprotectins A and B, together with a known compound complestatin, from the fermentation broth of Streptomyces sp. Q27107. Neuroprotectins protected primary cultured chick telencephalic neurons from glutamate- and kainate-induced excitotoxicities in a dose-dependant fashion.

ISSN 

0021-8820

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)