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Title 

Neuroprotectins A and B, bicyclohexapeptides protecting chick telencephalic neurons from excitotoxicity II : strucutre determination

Authors 

Hiroyuki KobayashiKazuo Shin-yaKazuo FurihataKoji NagaiKen-ichi SuzukiYoichi HayakawaHaruo SetoBong Sik YunIn Ja RyooJung Sik KimChang Jin KimIck Dong Yoo

Publisher 

Nature Publishing Group

Issue Date 

2001

Citation 

Journal of Antibiotics, vol. 54, no. 12, pp. 1019-1024

Keywords 

alanine derivativebicyclo compoundcomplestatinhexapeptidekainic acidneuroprotectin aneuroprotectin bneuroprotective agenttryptophanunclassified drug

Abstract 

In the course of our search for neuroprotective agents of microbial origin against kainate-induced neurotoxicity, we have succeeded in the isolation of two new bicyclohexapeptides, neuroprotectins A and B, together with a known compound, complestatin, from the fermentation broth of Streptomyces sp. Q27107. They are closely related in structure to complestatin and possess an oxindolylalanine moiety in place of the tryptophan residue present in complestatin.

ISSN 

0021-8820

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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