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Title 

Construction and analysis of a human-chimpanzee comparative clone map

Authors 

Asao FujiyamaHidemi WatanabeAtsushi ToyodaTodd D TaylorTakehiko ItohShih-Feng TsaiHong-Seog ParkMarie Laure YaspoHans LehrachZhu ChenGang FuNaruya SaitouKazutoyo OsoegawaPieter J de JongYumiko SutoMasahira HattoriYoshiyuki Sakaki

Publisher 

American Association for the Advancement of Science

Issue Date 

2002

Citation 

Science, vol. 295, no. 5552, pp. 131-134

Keywords 

bacteriaresearchgenetic informationprimatebacterial artificial chromosomechimpanzeefluorescence in situ hybridizationgene mappinghumanhuman genome

Abstract 

The recently released human genome sequences provide us with reference data to conduct comparative genomic research on primates, which will be important to understand what genetic information makes us human. Here we present a first-generation human-chimpanzee comparative genome map and its initial analysis. The map was constructed through paired alignment of 77,461 chimpanzee bacterial artificial chromosome end sequences with publicly available human genome sequences. We detected candidate positions, including two clusters on human chromosome 21 that suggest large, nonrandom regions of difference between the two genomes.

ISSN 

0036-8075

Link 

http://dx.doi.org/10.1126/science.1065199

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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