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Title | Citrinin hydrate inhibits serotonin N-acetyltransferase catalyzing the conversion of serotonin to N-acetylserotonin |
Authors | In Kyoung Lee; Bong Sik Yun; Kyong Tai Kim; Bo Hwa Choi; Tae Ju Park; Young Ho Kim; Ick Dong Yoo |
Publisher | The Korean Society for Applied Microbiology |
Issue Date | 2001 |
Citation | Journal of Microbiology and Biotechnology, vol. 11, no. 6, pp. 1099-1101 |
Keywords | citrinin hydrate; penicillium sp.; serotonin n-acetyltransferase (AA-NAT) inhibitor; aralkylamine acetyltransferase; citrinin; enzyme inhibitor; n acetylserotonin; proteinase inhibitor; serotonin; cell fractionation |
Abstract | In an attempt to search for serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AA-NAT) inhibitors from microbial metabolites, we found the culture broth of Penicillium sp. 80722 which showed a strong inhibitory activity against AA-NAT. The active principle has been identified as citrinin hydrate through bioassay-guided fractionation of cultural broth, and structure elucidation derived by spectroscopic analyses. Citrinin hydrate inhibits AA-NAT with an IC50 value of 173 μM in a dose-dependent manner. Although citrinin hydrate was previously isolated as human rhinovirus 3C-protease inhibitor, this was recognized as the first AA-NAT inhibitor isolated from natural sources. |
ISSN | 1017-7825 |
Appears in Collections | |
Registered Date |
2019-05-02 |
