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Title 

Citrinin hydrate inhibits serotonin N-acetyltransferase catalyzing the conversion of serotonin to N-acetylserotonin

Authors 

In Kyoung LeeBong Sik YunKyong Tai KimBo Hwa ChoiTae Ju ParkYoung Ho KimIck Dong Yoo

Publisher 

The Korean Society for Applied Microbiology

Issue Date 

2001

Citation 

Journal of Microbiology and Biotechnology, vol. 11, no. 6, pp. 1099-1101

Keywords 

citrinin hydratepenicillium sp.serotonin n-acetyltransferase (AA-NAT) inhibitoraralkylamine acetyltransferasecitrininenzyme inhibitorn acetylserotoninproteinase inhibitorserotonincell fractionation

Abstract 

In an attempt to search for serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AA-NAT) inhibitors from microbial metabolites, we found the culture broth of Penicillium sp. 80722 which showed a strong inhibitory activity against AA-NAT. The active principle has been identified as citrinin hydrate through bioassay-guided fractionation of cultural broth, and structure elucidation derived by spectroscopic analyses. Citrinin hydrate inhibits AA-NAT with an IC50 value of 173 μM in a dose-dependent manner. Although citrinin hydrate was previously isolated as human rhinovirus 3C-protease inhibitor, this was recognized as the first AA-NAT inhibitor isolated from natural sources.

ISSN 

1017-7825

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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