상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Anticomplement activity of terpenoids from the spores of Ganoderma lucidum

Authors 

Byung Sun MinJiang Jing GaoMasao HattoriHyeong Kyu LeeYoung Ho Kim

Publisher 

Georg Thieme Verlag

Issue Date 

2001

Citation 

Planta Medica, vol. 67, no. 9, pp. 811-814

Keywords 

anticomplementary activityganoderiol Fganoderma lucidumlanostane-type triterpenelucidenic acid SP1polyporaceaepanoderma lucidum extractganodermanondiolganodermanontriollucidumol

Abstract 

A new lanostane-type terpenoid, lucidenic acid SP1 (1), was isolated from a CHCl3-soluble fraction of Ganoderma lucidum spores together with four other known compounds (2-5). The structure of lucidenic acid SP1 was determined to be 3β,7β-dihydroxy-4,4,14α-trimethyl-11,15-dioxo-5α-chol- 8-en-24-oic acid by spectroscopic means including 2D-NMR. Twelve triterpenes (1-12) isolated from G. lucidum spores were investigated in vitro for their anticomplementary activity. Compounds 1-5 were inactive, whereas ganoderiol F (8), ganodermanondiol (9) and ganodermanontriol (10) showed a strong anticomplement activity against the classical pathway (CP) of the complement system with IC50 values of 4.8, 41.7, and 17.2 μM, respectively. The potency of these triterpene alcohols (8-10) in inhibiting CP activity was improved when the number of hydroxymethyl groups on the side chain moiety is increased. On the other hand, the ganoderic acids 1-7, which contain a carboxyl group in the side chain, and lucidumols A and B (11, 12) had little activity on this system.

ISSN 

0032-0943

Link 

http://dx.doi.org/10.1055/s-2001-18854

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)