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Title 

Cytotoxic triterpenoides from Alismatis Rhizoma

Authors 

Sang Myung LeeYung Hee KhoByung Sun MinJin Hee KimMin Kyun NaShin Jyung KangHack Young MaengKi Hwan Bae

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2001

Citation 

Archives of Pharmacal Research, vol. 24, no. 6, pp. 524-526

Keywords 

alismatis rhizomaalisol bcytotoxicity

Abstract 

Four prostane-type triterpenes were isolated from a methanol extract of Alismatis Rhizoma by bioassay-guided isolation using in vitro cytotoxic assay. The compounds were identified as alisol B 23-acetate (1), alisol C 23-acetate (2), alisol B (3), alisol A 24-acetate (4) by spectroscopic methods. Amongst the compounds, alisol B (3) showed significant cytotoxicity against SK-OV3, B16-F10, and HT1080 cancer cell lines with ED50 values of 7.5, 7.5, 4.9 μg/ml, respectively.

ISSN 

0253-6269

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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