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Title 

A cytotoxic secocycloartenoid from Abies koreana

Authors 

Hyun Jung KimQuoc Khanh LeMi Hyun LeeTae Sung KimHyeong Kyu LeeYoung Ho KimKi Hwan BaeIk Soo Lee

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2001

Citation 

Archives of Pharmacal Research, vol. 24, no. 6, pp. 527-531

Keywords 

24-methylene-3,4-seco-cycloart-4(28)-en-3-oic acid3- Oxo-9β-lanosta-7,22z,24-trien-26,23-olideabies koreanacytotoxicitypinaceae24 methylene 3,4 secocycloart 4(28) en 3 oic acid3 oxolanosta 7,22,24 trien 26,23 olideantineoplastic agentabieshuman

Abstract 

Two triterpenoids, 24-methylene-3,4-seco-cycloart-4(28)-en-3-oic acid (1) and 3-oxo-9β- lanosta-7,22Z,24-trien-26,23-olide (6) were isolated from Abies koreana, together with β- sitosterol (2), maltol (3), β-sitosterol-O-β-D-glucoside (4), and hexacosylferulate (5). The structures of the compounds were established based on the spectroscopic data. The cytotoxic activities of triterpenoids have been evaluated using the sulforhodamine B (SRB) method. Compound 1 showed moderate cytotoxicities against human lung carcinoma (A549), ovarian carcinoma (SK-OV-3), malignant melanoma (SK-MEL-2), and colon carcinoma (HCT-15) cell lines.

ISSN 

0253-6269

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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