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Title 

Kalopanaxsaponin A from Kalopanax pictus, a potent antioxidant in the rheumatoidal rat treated with Freund's complete adjuvant reagent

Authors 

Jong Won ChoiKeun HuhSuk Hwan KimKyung Tae LeeHyeong Kyu LeeHee Juhn Park

Publisher 

Elsevier

Issue Date 

2002

Citation 

Journal of Ethnopharmacology, vol. 79, no. 1, pp. 113-118

Keywords 

Freund's adjuvant reagentKalopanax pictusKalopanaxsaponin Amicrosomaloxidative stressrheumatoidal arthritisaldehyde oxidaseantioxidantantirheumatic agentcatalase

Abstract 

The stem bark of Kalopanax pictus is an anti-rheumatoidal arthritis drug in Oriental medicine. In the rheumatoidal rat, induced by Freund's complete adjuvant (FCA) reagent, we investigated the effects of hederagenin monodesmosides of K. pictus on oxidative stress and hepatic drug-metabolizing enzymes. Kalopanaxsaponin-A (KPS-A) significantly decreased malondialdehyde formation and the activities of xanthine oxidase and aldehyde oxidase of hepatic non-microsomal systems in FCA reagent-treated rats. In addition, increased activity levels of superoxide dismutase, catalase and glutathione peroxidase were also observed. The effects of KPS-A were more potent than the effects of KPS-I. These results suggested that KPS-A, extracted from K. pictus, could reduce rheumatoidal syndromes through antioxidative mechanisms.

ISSN 

0378-8741

Link 

http://dx.doi.org/10.1016/S0378-8741(01)00382-8

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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