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Title 

Kaposi's sarcoma-associated herpesvirus open reading frame 50 stimulates the transcriptional activity of STAT3

Authors 

You Sang GwackSeung Min HwangChung Hun LimYoung Suk WonChul Ho LeeJoon Ho Choe

Publisher 

American Society for Biochemistry and Molecular Biology

Issue Date 

2002

Citation 

Journal of Biological Chemistry, vol. 277, no. 8, pp. 6438-6442

Keywords 

genesmonomersproteinsphosphorylationvirusesSTAT3 proteincorrelation analysisepstein Barr virusgenetic transcriptionhuman herpesvirus 8

Abstract 

Kaposi's sarcoma-associated herpesvirus (KSHV) is an important pathogen in Kaposi's sarcoma and abnormal lymphoproliferation. KSHV open reading frame 50 (ORF50), a homolog of the Epstein-Barr virus immediate-early gene product RTA, activates early and late gene transcription in the KSHV lytic cycle, and its expression is closely correlated with KSHV-related diseases. ORF50 interacts with the cellular proteins CBP and histone deacetylase and represses p53-induced apoptosis through a CBP-related mechanism. We show here that KSHV ORF50 also interacts with STAT3. ORF50 stimulated transcription of STAT-driven reporter genes, and interleukin-6 and v-Src further activated this stimulating effect of ORF50. Physical association of STAT3 and ORF50 required the carboxyl-terminal transactivation domain of ORF50 and multiple regions within STAT3. ORF50 recruited STAT3 to the nucleus and induced the dimerization of STAT3 monomers in the absence of STAT3 phosphorylation. We show here that KSHV ORF50 activates STAT3-mediated transcription through direct interaction without mediating tyrosine phosphorylation.

ISSN 

0021-9258

Link 

http://dx.doi.org/10.1074/jbc.M108289200

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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