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Title 

Furanoligularenone, an eremophilane from Ligularia fischeri, inhibits the LPS-induced production of nitric oxide and prostaglandin E2 in macrophage RAW264.7 cells

Authors 

Bang Yeon HwangJeong Hyung LeeTae Hyeon KooHang Sub KimYoung Soo HongJai Seup RoKyong Soon LeeJung Joon Lee

Publisher 

Georg Thieme Verlag

Issue Date 

2002

Citation 

Planta Medica, vol. 68, no. 2, pp. 101-105

Keywords 

compositaecyclooxygenase-2furanoligularenoneinducible nitric oxide synthaseligularia fischeriNF-κBnitric oxideprostaglandin E23 oxo 8alpha hydroxy 10alphah eremophila 1,7(11) dien 12,8beta olide3 oxo 8alpha methoxy 10alphah eremophila 1,7(11) dien 12,8beta olide

Abstract 

Furanoligularenone (1), a known eremophilane, was identified from Ligularia fischeri (Compositae) together with 3-oxo-8α-hydroxy-10αH-eremophila-1,7(11)-dien-12,8β-olide (2) and 3-oxo-8α-methoxy-10αH-eremophila-1,7(11)-dien-12,8β-olide (3), by its potent inhibition of LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production in RAW 264.7 cells. Compound 1 also suppressed the expression of iNOS and COX-2 mRNA and protein in a dose-dependent manner. Taken together, compound 1 inhibits the production of NO and PGE2 at the transcription of iNOS and COX-2 genes, and would be responsible for the anti-inflammatory activities of the Ligularia fischeri.

ISSN 

0032-0943

Link 

http://dx.doi.org/10.1055/s-2002-20250

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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