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Title 

Antiinflammatory constituents of Celastrus orbiculatus inhibit the NF-κB activation and NO production

Authors 

Hui Zi JinBang Yeon HwangHang Sub KimJeong Hyung LeeYoung Ho KimJung Joon Lee

Publisher 

American Chemical Society

Issue Date 

2002

Citation 

Journal of Natural Products, vol. 65, no. 1, pp. 89-91

Keywords 

1beta acetoxyl 2beta,6alpha,9alpha trifuroyloxydihydro beta agarofuran1beta,8beta diacetoxyl 6alpha,9alpha difuroyloxydihydro beta agarofurancelaphanol Acelastrus orbiculatus extractherbaceous agentimmunoglobulin enhancer binding proteinantiinflammatory activityenzyme activationenzyme inhibitionnonhumananti-inflammatory agents, non-steroidal

Abstract 

Two new sesquiterpene esters, 1β,8β-diacetoxyl-6α,9α-difuroyloxydihydro-β- agarofuran (1) and 1β-acetoxyl-2β,6α,9α-trifuroyloxydihydro-β- agarofuran (2), together with four known sesquiterpene esters (3-6), celastrol (7), and celaphanol A (8) were isolated from the roots of Celastrus orbiculatus in a search for inhibitors of NF-κB activation and nitric oxide production. Compound 7 was the most active, while compounds 1, 2, 4, and 8 showed moderate inhibition in both NF-κB activation and nitric oxide production.

ISSN 

0163-3864

Link 

http://dx.doi.org/10.1021/np010428r

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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