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Title 

Genomic DNA sequence and transcription factor binding sites of mouse Ninjurin

Authors 

Ae Ran MoonGoo Taeg OhJae Wha KimYoung Jin ChoiIn Seong Choe

Publisher 

Taylor & Francis

Issue Date 

2001

Citation 

DNA Sequence, vol. 12, no. 5, pp. 385-395

Keywords 

genomic DNAninjurinpromotertranscription factornerve growth factorninj1 protein, mouseamino acid sequencebinding siteDNA sequence

Abstract 

The complete genomic DNA sequence of mouse ninjurin gene has been cloned and sequenced by screening a bacterial artificial chromosome (BAC) library of mouse 129/SvJ genomic DNA. The mouse ninjurin gene comprises four exons and the translatable sequences are included in the first three exons. The putative promoter region of the mouse ninjurin gene lacks the consensus "CAAT" or "TATA" sequence. Nonetheless, it has demonstrated the promoter activity in transient transfection experiment using the construct containing putative promoter sequence of mouse ninjurin and reporter gene. The nucleotide sequence of the putative promoter region shows 83% homology with the corresponding DNA sequence of human ninjurin gene that had been previously reported, and reveals a high degree of conservation between the two species. Analysis of the DNA sequence identified the putative promoters and the binding sites for a variety of transcription factors of mouse ninjurin.

ISSN 

1042-5179

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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