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Title 

Effect of rutin and tannic acid supplements on cholesterol metabolism in rats

Authors 

Sun Young ParkSong Hae BokSoen Min JeonYong Bok ParkSoon Jae LeeTae Sook JeongMyung Sook Choi

Publisher 

Elsevier

Issue Date 

2002

Citation 

Nutrition Research, vol. 22, no. 3, pp. 283-295

Keywords 

ACATantioxidant enzymesfecal sterolsHMG-CoA reductaserutintannic acidcholesterol acyltransferasecholesterol metabolismdiet supplementationratAntioxidant enzymes

Abstract 

This study was designed to test the lipid-lowering and antioxidative activities of two phenolic compounds, rutin and tannic acid. Three groups of rats were given a semisynthetic diet containing 1 g of cholesterol/kg for 5 wks. The control group only received a high cholesterol diet, whereas the other two groups received a diet including 1 g of rutin or 1 g of tannic acid/kg. The rutin and tannic acid both significantly lowered the plasma lipid and hepatic cholesterol levels compared to those in the control. The hepatic HMG-CoA reductase activity was significantly lower in the tannic acid group than in the rutin group, while the hepatic ACAT activity was significantly lower in both the rutin and tannic groups compared to the control group. The overall potential of the antioxidant system was significantly enhanced by the rutin and tannic acid supplements as the plasma and hepatic TBARS levels were lowered while the hepatic SOD and GSH-Px activities were increased in the high-cholesterol fed rats. Furthermore, these results suggest that the supplementation of rutin and tannic acid promoted the excretion of fecal sterols, thereby leading to a decreased absorption of dietary cholesterol as well as lower plasma and hepatic cholesterol.

ISSN 

0271-5317

Link 

http://dx.doi.org/10.1016/S0271-5317(01)00398-0

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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