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Title 

Supplementation of naringenin and its synthetic derivative alters antioxidant enzyme activities of erythrocyte and liver in high cholesterol-fed rats

Authors 

Mi Kyung LeeSong Hae BokTae Sook JeongSurk Sik MoonSeung Eun LeeYong Bok ParkMyung Sook Choi

Publisher 

Elsevier

Issue Date 

2002

Citation 

Bioorganic & Medicinal Chemistry, vol. 10, no. 7, pp. 2239-2244

Keywords 

naringeninnaringenin 7 o cetyl etherantioxidant activitycholesterol dietenzyme activityerythrocyteratantioxidantscholesterol, dietaryerythrocytes

Abstract 

The antioxidative effects of naringenin (1) and its synthetic derivative, naringenin 7-O-cetyl ether (2), were tested. Male rats were fed a 1 g/100 g high-cholesterol diet for 6 weeks with supplements of either 1 or 2 (0.073 mmol/100 g diet) to study the effects on the antioxidant enzyme activities in the erythrocyte and liver. The erythrocyte catalase (CAT) and superoxide dismutase (SOD) activities were significantly higher in the compounds 1 or 2 supplemented groups than in the control group, whereas the hepatic SOD and CAT activities were significantly lower in the compound 2 supplemented group. The compounds 1 and 2 supplements to a high cholesterol diet lowered or tended to lower the plasma TBARS levels, that is, lipid peroxide products, while enhancing the plasma paraoxonase activity. These results indicate that the supplementation of 1 and 2 was effective in improving the antioxidant capacity of the erythrocyte and liver, plus the synthetic functional compound 2 appeared to be as potent as 1 in enhancing the antioxidant defense system.

ISSN 

0968-0896

Link 

http://dx.doi.org/10.1016/S0968-0896(02)00059-7

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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