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Title 

Agastinol and agastenol, novel lignans from Agastache rugosa and their evaluation in an apoptosis inhibition assay

Authors 

Choong Hwan LeeHyun A KimYung Hee Kho

Publisher 

American Chemical Society

Issue Date 

2002

Citation 

Journal of Natural Products, vol. 65, no. 3, pp. 414-416

Keywords 

agastenolagastinolapoptosis inhibitorapoptosisinhibition kineticslignansagastacheagastache rugosa

Abstract 

Investigation of the whole plant of Agastache rugosa resulted in the isolation of two new lignan compounds. Their structures were elucidated as (8S, 7′R, 8′S)-4-hydroxybenzoic acid 4-(4-hydroxy-3-methoxybenzyl)2-(4-hydroxy-3-methoxyphenyl) tetrahydrofuran-3-ylmethyl ester (agastinol, 1) and (7′R, 8′S)-4-hydroxybenzoic acid 4-(hydroxy-3-methoxybenzylidene)-2-(4-hydroxy-3-methoxyphenyl)- tetrahydrofuran-3ylmethyl ester (agastenol, 2). Agastinol and agastenol inhibited etoposide-induced apoptosis in U937 cells with IC50 values of 15.2 and 11.4μg/mL, respectively.

ISSN 

0163-3864

Link 

http://dx.doi.org/10.1021/np010425e

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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