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Title 

Novel α-glucosidase inhibitors, CKD-711 and CKD-711a produced by Streptomyces sp. CK-4416 III : physico-chemical properties and structure elucidation

Authors 

Hung Bae ChangSun Ho KimYoung In KwonDong Ho ChoungWon Kyu ChoiTae Won KangSung Sook LeeJong Gwan KimHyoung Sik ChunSoon Kil AhnChung Il HongKyou Hoon Han

Publisher 

Nature Publishing Group

Issue Date 

2002

Citation 

Journal of Antibiotics, vol. 55, no. 5, pp. 467-471

Keywords 

alpha glucosidase inhibitorckd 711ckd 711adrug structuremass spectrometrynuclear magnetic resonance spectroscopystreptomycesalpha-glucosidasesenzyme Inhibitorsmagnetic resonance spectroscopy

Abstract 

We have isolated two novel α-glucosidase inhibitors, O-[4-deoxy-4-(2,3-epoxy-3-hydroxymethyl-4,5,6-trihydroxycyclohexane- 1-y1-amino)-α-D-glucopyranosyl]- (1→4)-O-α-D-glucopyranosyl- (1→4)-α-D-glucopyranose (named CKD-711) and its hexameric analog CKD-711a, from the fermentation broth of Streptomyces sp. CK-4416. HRFAB-MS and NMR analyses reveal that molecular formulae of CKD-711 and CKD-711a are C25H43NO20 and C37H63NO30, respectively with the latter containing two more glucose moieties than the former. Detailed chemical structures of both compounds have been characterized by high-resolution two-dimensional NMR methods.

ISSN 

0021-8820

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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