상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Synthesis and anti-tumor activity of novel combretastatins : combretocyclopentenones and related analogues

Authors 

Nguyen Hai NamYong KimYoung Jae YouDong Ho HongHwan Mook KimByung Zun Ahn

Publisher 

Elsevier

Issue Date 

2002

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 12, no. 15, pp. 1955-1958

Keywords 

antimitotic agentantineoplastic agentantineoplastic activitydrug synthesisstructure activity relationtumor cell linesynthesisantineoplastic agentsdrug screening assays, antitumorstructure-activity relationship

Abstract 

A series of 2-(3,4,5-trimethoxyphenyl)-3-arylcyclopent-2-ene-1-ones (8a-8e) and their related analogues, including pentenone 9a, pentenol 10a, pentene 12a, and furane 15, were synthesized and evaluated for cytotoxicity against murine and human tumor cell lines. Compounds 8a-c, 8e and 9a showed strong cytotoxicity with IC50 values in the range of 8-34 ng/mL. Compound 8e exhibited significant anti-tumor activity in BDF1 mice bearing Lewis lung carcinoma cells with an inhibition ratio of 59%.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/S0960-894X(02)00321-9

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)