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Title 

Aceriphyllic acid A, a new ACAT inhibitory triterpenoid, from Aceriphyllum rossii

Authors 

Jae Taek HanHae Yeong KimYoung Doo ParkYoun Hyung LeeKang Ro LeeByoung-Mog KwonNam In Baek

Publisher 

Georg Thieme Verlag

Issue Date 

2002

Citation 

Planta Medica, vol. 68, no. 6, pp. 558-561

Keywords 

3 oxoolean 12 en 27 oic acid3alpha hydroxyolean 12 en 27 oic acid3alpha,23 dihydroxyolean 12 en 27 oic acid3alpha,23 dihydroxyolean 12 en 29 oic acid3beta hydroxyolean 12 en 27 oic acidaceriphyllic acid aaceriphyllum rossii extractcholesterol acyltransferasetriterpenoidunclassified drug

Abstract 

Two new triterpenoids along with three known ones, 3-oxo-olean-12-en-27-oic acid (1), 3α-hydroxyolean-12-en-27-oic acid (2) and 3β-hydroxyolean-12-en-27-oic acid (3), were isolated from Aceriphyllum rossii. The structures of the new compounds were determined to be a 3α,23-dihydroxyolean-12-en-27-oic acid (4) and a 3α,23-dihydroxyolean-12-en-29-oic acid (5) by spectroscopic and chemical methods; they were designated aceriphyllic acids A and B, respectively. Compounds 2, 3 and 4 remarkably inhibited the activity of ACAT.

ISSN 

0032-0943

Link 

http://dx.doi.org/10.1055/s-2002-32565

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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