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Title 

Atroviridins A~C and neoatroviridins A~D, novel peptaibol antibiotics produced by Trichoderma atroviride F80317 : 1. taxonomy, fermentation, isolation and biological activities

Authors 

Seung Uk OhBong Sik YunSang Jun LeeJung Han KimIck Dong Yoo

Publisher 

Nature Publishing Group

Issue Date 

2002

Citation 

Journal of Antibiotics, vol. 55, no. 6, pp. 557-564

Keywords 

amino acidantibiotic agentantineoplastic agentatroviridin aatroviridin batroviridin catroviridin derivativeneoatroviridinneoatroviridin derivativepeptaibol

Abstract 

Seven new peptaibols, atroviridins A-C composed of 20 residue amino acids and neoatroviridins A-D with 18 residues, were isolated from the culture broth of fungal strain F80317. The strain F80317 was identified as Trichoderma atroviride from its morphological and cultural characteristics. These compounds showed antimicrobial activity against Gram-positive bacteria and phytopathogenic fungi, and exhibited significant cytotoxicity to human cancer cell lines in vitro. Atroviridins showed significant membrane-perturbing activity responsible to their antibiotic action.

ISSN 

0021-8820

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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