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Title 

Molecular phylogeny of endogenous retrovirus HERV-F family in japanese and rhesus monkeys

Authors 

Heui Soo KimSeung Heui JeonJoo Mi YiTae Hyeong KimMyung Sook KimByung Hwa HyunOsamu Takenaka

Publisher 

The Genetics Society of Korea

Issue Date 

2002

Citation 

Korean Journal of Genetics, vol. 24, no. 2, pp. 133-139

Keywords 

HERV-F familyHu-XA34japanese and rhesus monkeysphylogenyprimate evolutionmolecular cloningmolecular phylogenyretrovirusrhesus monkeymacaca fuscata

Abstract 

A new human endogenous retroviral family (HERV-F) has recently been identified from the human chromosome 7q31.1-q31.3 that was identical to the XA34 cDNA clone isolated from a human glioma cDNA library with an ERV-9 probe. The current study investigated pol fragments of the HERV-F family from Japanese and rhesus monkeys and compared them with those of the HERV-F (Hu-XA34) family. Fourteen pol fragments of the HERV-F family were detected from the monkeys, which showed a 78.7 - 95.4% sequence similarity with those of HERV-F (Hu-XA34). Clones FJM-1, FJM-7, FJM-14, and FJM-15 from the Japanese monkey and FRH-1 and FRH-4 from the rhesus monkey exhibited no disruption due to point mutation or insertions/deletions. The ratio of synonymous to non-synonymous substitutions indicated that negative selective pressure was acting on these clones. Therefore, the pol gene sequences could be associated with an active provirus in the monkey genomes. A phylogenetic analysis of the pol fragments from humans and monkeys using the neighbor-joining and maximum parsimony methods showed six groups, indicating that either the HERV-F family was amplified at least six times after its original integration into the monkey genome or the occurrence of independent integration events during primate evolution.

ISSN 

0254-5934

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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