상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Biological effects of G1 phase arrest compound, sesquicillin, in human breast cancer cell lines

Authors 

Ha Won JeongHo Jae LeeYung Hee KhoKwang Hee SonMi Young HanJong-Seok LimMi Young LeeDong Cho HanJ H HaByoung-Mog Kwon

Publisher 

Elsevier

Issue Date 

2002

Citation 

Bioorganic & Medicinal Chemistry, vol. 10, no. 10, pp. 3129-3134

Keywords 

sesquicillinCDKN1A protein, humancyclinebreast cancercell culturecell cycle G1 phasehumanhuman celltumor cell linebreast tumor

Abstract 

Sesquicillin, isolated from fumgal fermentation broth, strongly induced G1 phase arrest in human breast cancer cells. During G1 phase arrest, the expression level of cyclin D1, cyclin A, and cyclin E was decreased, and the expression of CDK (cyclin-dependent-kinase) inhibitor, protein p21Waf1/Cip1, was increased in a time-dependent manner in a breast cancer cell MCF-7. Interestingly, the G1 phase arrest induced by swsquicillin also occurred independently of the tumor suppressor protein, p53. Sesquicillin inhibits the proliferation of MCF-7 via G1 phase arrest in association with the induction of CDK inhibitor protein, p21Waf1/Cip1, and the reduction of G1 phase related-cyclin proteins.

ISSN 

0968-0896

Link 

http://dx.doi.org/10.1016/S0968-0896(02)00225-0

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)