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Title 

Effects of oleanane-type triterpenoids from fabaceous plants on the expression of ICAM-1

Authors 

Kyung Seop AhnJung Hee KimSei Ryang OhByung Sun MinJ KinjoHyeong Kyu Lee

Publisher 

Pharmaceutical Society of Japan

Issue Date 

2002

Citation 

Biological & Pharmaceutical Bulletin, vol. 25, no. 8, pp. 1105-1107

Keywords 

fabaceous plantintercellular adhesion moleculeoleanane-type triterpenoidintercellular adhesion molecule 1plant extractoleananeantigen expressiondrug effectgene expression regulationplant

Abstract 

We examined the inhibitory effects of oleanane-type triterpenoids from fabaceous plants on the TNF-α-induced expression of cell adhesion molecules on THP-1 human monocytic leukemia cells and compared them with a glucocorticoid dexamethasone. In a cell-based ELISA, abrisapogenol E, soyasapogenols B and C, soyasapogenol B, kuzusapogenol B-methyl ester, and oleanolic acid significantly inhibited intercellular adhesion molecule (ICAM-1) expression. Moreover, these triterpenoids showed the same activity as dexamethasone. On the other hand, the absence of hydroxyl group at C-24 position of sapogenin rather to increase ICAM-1 expression compared with the untreated control. We concluded that the activity of oleanane saponins and sapogenins against ICAM-1 expression are dependent upon the position of the hydroxyl group, and in particular upon the status of the C-21 and C-24 positions and of the glycosyl group at C-3 position.

ISSN 

0918-6158

Link 

http://dx.doi.org/10.1248/bpb.25.1105

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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