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Title 

Aberrant allocations of inner cell mass and trophectoderm cells in bovine nuclear transfer blastocysts

Authors 

Deog Bon KooYong Kook KangYoung Hee ChoiJung Sun ParkH N KimK B OhD S SonH ParkKyung Kwang LeeYong Mahn Han

Publisher 

Society for the Study of Reproduction

Issue Date 

2002

Citation 

Biology of Reproduction, vol. 67, no. 2, pp. 487-492

Keywords 

developmental biologyearly developmentembryoimplantationtrophoblastanimal cellblastocystcell countcell nucleus transplantationinner cell mass

Abstract 

Abortions of nuclear transfer (NT) embryos are mainly due to insufficient placentation. We hypothesized that the primary cause might be the aberrant allocations of two different cell lineages of the blastocyst stage embryos, the inner cell mass (ICM) and the trophectoderm (TE) cells. The potential for development of NT embryos to blastocysts was similar to that for in vitro fertilized (IVF) embryos. No difference in the total cell number was detected between NT and IVF blastocysts, but both types of embryos had fewer total cells than did in vivo-derived embryos (P < 0.05). The NT blastocysts showed a higher ratio of ICM:total cells than did IVF or in vivo-derived embryos (P < 0.05). Individual blastocysts were assigned to four subgroups (1: <20%, II: 20-40%, III: 40-60%, IV: >60%) according to the ratio of ICM:total cells. Most NT blastocysts were placed in groups III and IV, whereas most IVF and in vivo-derived blastocysts were distributed in group II. Our findings suggest that placental abnormalities or early fetal losses in the present cloning system may be due to aberrant allocations of NT embryos to the ICM and TE cells-during early development.

ISSN 

0006-3363

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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