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Title 

Fungal metabolites, asterric acid derivatives inhibit vascular endothelial growth factor(VEGF)-induced tube formation of HUVECs

Authors 

Hee Jung LeeJeong Hyeong LeeBang Yeon HwangHang Sub KimJung Joon Lee

Publisher 

Nature Publishing Group

Issue Date 

2002

Citation 

Journal of Antibiotics, vol. 55, no. 6, pp. 552-556

Keywords 

3 chloroasterric acid3,5 dichloroasterric acidangiogenesis inhibitorasterric acid derivativemethyl asterric acidfungal straininhibition kineticsendothelial growth factorsendothelium, vascularvascular endothelial growth factor A

Abstract 

In the search for new naturally occurring anti-angiogenic compounds, we found that a culture broth of an unidentified fungal strain B90911 exerted inhibitory activity on capillary-like tube formation of human umbilical vein endothelial cells (HUVEC) in vitro. Four active compounds were isolated by bioassay-guided separation and their structures were identified to be sulochrin (1), methyl asterric acid (2), and two new asterric acid derivatives, 3-chloroasterric acid (3), and 3,5-dichloroasterric acid (4) by spectroscopic analyses. These compounds significantly inhibited the VEGF-induced tube formation of HUVEC, suggesting that asterric derivatives could be useful for further study as anti-angiogenic agents.

ISSN 

0021-8820

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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