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Title 

Etoposide activates caspase-3 via a caspase-1 independent mechanism in cancer cells

Authors 

Sang-Han LeeKyu Tae ChangO Y KwonT K Kwon

Publisher 

Korean Society for Brain and Neural Science

Issue Date 

2002

Citation 

Experimental Oncology, vol. 24, no. 2, pp. 105-107

Keywords 

apoptosiscaspase-1caspase-3etoposidecaspase 3Fas antibodyinterleukin 1beta converting enzymeantineoplastic activitycancer cell

Abstract 

It is known that caspase-1 is activated before caspase-3 activation when the cells were treated with anti-Fas-antibody. In present study the activities of these two proteases in etoposide-treated cells were examined. It has been shown that whilst treatment of U937 and Jurkat cells with etoposide results in caspase-3 activation it did not influence caspase-1 activity. At the same time treatment of U937 cells with anti-Fas antibody induces caspase-1 activity. These results demonstrate that etoposide transmits the death signal to caspase-3 directly, suggesting that caspase-3 was activated by a caspase-1 independent mechanism during etoposide-induced apoptosis.

ISSN 

0204-3564

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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