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Title 

Inhibitory activity of diacylglycerol acyltransferase by tanshinones from the root of Salvia miltiorrhiza

Authors 

Jeong Suk KoS Y RyuY S KimMi Yeon ChungJ S Kang Rho Mun ChualHyun Sun LeeYoung Kook Kim

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2002

Citation 

Archives of Pharmacal Research, vol. 25, no. 4, pp. 446-448

Keywords 

diacylglycerol acyltransferaselabiataesalvia miltiorrhizatanshinonesacyltransferaseplant rootsalviadiacylglycerol o-acyltransferaseplant roots

Abstract 

The inhibitory activity of tanshinones from Salvia miltiorrhiza was tested on rat liver diacylglycerol acyltransferase (DGAT). Cryptotanshinone (1) and 15,16-dihydrotanshinone I (3) exhibited potent DGAT inhibitory activities dose-dependently with IC50 values of 10.5 μg/ml and 11.1 μg/ml. However, tanshinone IIA (2) and tanshinone I (4) showed very weak inhibition (IC50 value: > 250 μg/ml). A dihydrofuran moiety was seemed to be responsible for the stronger inhibitory activity.

ISSN 

0253-6269

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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