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Title 

Arteminolides B, C, and D, new inhibitors of farnesyl protein transferase from Artemisia argyi

Authors 

Seung Ho LeeHyae Kyeong KimJeong Min SeoHyun Mi KangJong Han KimKwang Hee SonH S LeeByoung-Mog KwonJ H ShinY W Seo

Publisher 

American Chemical Society

Issue Date 

2002

Citation 

Journal of Organic Chemistry, vol. 67, no. 22, pp. 7670-7675

Keywords 

cellschemical bondsplants (botany)spectroscopic analysisinhibitory activityarteminolide Barteminolide Carteminolide Dprotein farnesyltransferase inhibitorsesquiterpene lactone

Abstract 

Arteminolides B-D (2-4), new farnesyl protein transferase inhibitors, were isolated together with a known arteminolide A (1) and new regioisomers (5-7) of the compounds from the aerial parts of Artemisia argyi. Structures of these compounds were elucidated by spectroscopic methods and chemical conversion. Arteminolides inhibited the farnesyl protein transferase with IC50 values of 0.7-1/ μM, while the regioisomers 5-7 were inactive. In addition, it was proved that the exocyclic double bond of sesquiterpene lactone did not affect the inhibitory activity of arteminolide. The effects of compound 2 on H-Ras processing and cellular growth in H-ras-transformed cells were also evaluated.

ISSN 

0022-3263

Link 

http://dx.doi.org/10.1021/jo020299z

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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