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Title 

Cytotoxic sesquiterpene lactones form Carpesium abrotanoides

Authors 

J S LeeByung Sun MinSang Myung LeeM K NaByoung-Mog KwonC O LeeY H KimK H Bae

Publisher 

Georg Thieme Verlag

Issue Date 

2002

Citation 

Planta Medica, vol. 68, no. 7, pp. 745-747

Keywords 

sesquiterpene lactonecytotoxicitylactonessesquiterpenes

Abstract 

Eight sesquiterpene lactones, 4α,5α-epoxy-10α,14-dihydro-inuviscolide (1), 2,3-dihydroaromomaticin (2), carpesiolin (3), carabrone (4), carabrol (5), telekin (6), ivalin (7) and 11,13-didehydroivaxillin (8), were isolated from the aerial parts of Carpesium abrotanoides Linne (Compositae). In vitro cytotoxicity testing was carried out against L1210, A549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15 tumor cell lines. Sesquiterpene lactone compounds 1 - 8 showed significant cytotoxic activity (ED50 values, < 20 μM) against all tumor call lines tested. Among these compounds, 4α, 5α-epoxy-10α,14-dihydro-inuviscolide (1), 2,3-dihydroaromomaticin (2), telekin (6) and ivalin (7) showed cytotoxic activity (ED50, < 10 μM) comparable to that of cisplatin.

ISSN 

0032-0943

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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