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Title 

Isolation of Acyl-CoA:Cholesterol Acyltransferase inhibitor from Persicaria vulgaris

Authors 

Hye Young SongMun Chual RhoSeung Woong LeeOh Eok KwonY D ChangHyun Sun LeeYoung Kook Kim

Publisher 

Georg Thieme Verlag

Issue Date 

2002

Citation 

Planta Medica, vol. 68, no. 9, pp. 845-847

Keywords 

cholesterol acyltransferasecholesterol acyltransferase inhibitorpersicaria vulgaris extractdrug isolationsterol O-Acyltransferasepersicariapolygonum persicaria

Abstract 

In the course of our search for Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors from natural sources, a new type of ACAT inhibitor was isolated from the methanol extract of Persicaria vulgaris. On the basis of spectral evidence, the structure of the active compound was identified as pheophorbide A. Pheophorbide A inhibited ACAT activity with an IC50 value of 1.1 μg/ml in an enzyme assay using rat liver microsomes with a dose dependent fashion.

ISSN 

0032-0943

Link 

http://dx.doi.org/10.1055/s-2002-34395

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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