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Title 

Eucosterol oligoglycosides isolated from Scilla scilloides and their anti-tumor activity

Authors 

Sang Myung LeeHyo Kon ChunChoong Hwan LeeByung Sun MinE S LeeYung Hee Kho

Publisher 

Pharmaceutical Society of Japan

Issue Date 

2002

Citation 

Chemical & Pharmaceutical Bulletin, vol. 50, no. 9, pp. 1245-1249

Keywords 

anti-tumor activityscilla scilloidesspirocyclic nortriterpenoide15 deoxo 30 hydroxyeucosterol 3 o alpha levo rhamnopyranosyl (1-2) [beta dextro glucopyranosyl (1-3)] beta dextro glucopyranosyl (1-2) alpha levo arabinopyranosyl (1-6) beta dextro glucopyranosideantineoplastic agenteucosterol oligoglycosidescilla scilloides extractantineoplastic activitytumor cell

Abstract 

Two new eucosterol oligoglycosides, 15-deoxo-30-hydroxyeucosterol 3-O-α-L-rhamnopyranosyl-(1→2)-[( β-Dglucopyranosyl-(1→3)]- β-D-glucopyranosyl-(1→2)-α-L-arabinopyranosyl-(1→6) -β-D-glucopyranoside (scillanoside L-1, 1) and 3 β,31-dihydroxy-17 α,23-epoxy-5α-lanost-8-en-23,26-olactone 3-O- α-L- rhamnopyranosyl-(1→2)-[ β-D-glucopyranosyl-(1→3)]- β-D-glucopyranosyl-(1→2)-α-L-arabinopyranosyl-(1→6) -β-D-glucopyranoside (scillanoside L-2, 2), were isolated from the bulbs of Scilla scilloides, together with four that were known (3-6), have been isolated from the bulbs of Scilla scilloides. The structures of the new compounds were determined on the basis of spectroscopic and chromatographic methods, and some chemical transformations were discussed. Amongst the isolated compounds, 3 showed the most significant cytotoxicity against tumor cells tested several types with ED50 value of 1.53-3.06 nM. In vivo experiments, 3 apparently increased the life span of mice bearing Sarcoma 180 tumor cell with T/C value of 239% at dose of 3 mg/kg.

ISSN 

0009-2363

Link 

http://dx.doi.org/10.1248/cpb.50.1245

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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