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Title 

Saeng-maek-san, a medicinal herb complex, protects liver cell damage induced by alcohol

Authors 

K J ParkM J LeeH M KangK S KimSang-Han LeeI H ChoH H Lee

Publisher 

Pharmaceutical Society of Japan

Issue Date 

2002

Citation 

Biological & Pharmaceutical Bulletin, vol. 25, no. 11, pp. 1451-1455

Keywords 

alcoholrat liver cellSaeng-Maek-Sanalanine aminotransferasealcohol dehydrogenaseaspartate aminotransferasefat dropletherbaceous agentsaeng maek san

Abstract 

The effect of treatment with Saeng-Maek-San (SMS) Complex (SMS1 or SMS2) upon rat hepatocytes exposed to alcohol was investigated. We compared the serum biochemistry and liver histology of rats administered both alcohol and SMS to control rats treated with alcohol alone. SMS treatment resulted in a significant reduction in the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and triglycerides (TG) compared to the control rats. In contrast, expression levels of alcohol dehydrogenase (ADH) were increased. Electron microscopy indicated that administration of SMS preserved the structure of organelles, including the nucleus and mitochondria. In addition, lipid droplets and secondary lysosomes were observed in the control rats. These data suggest that SMS represents an excellent candidate for protection of rat hepatocytes from alcohol-mediated damage.

ISSN 

0918-6158

Link 

http://dx.doi.org/10.1248/bpb.25.1451

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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