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Title 

Brine shrimp lethality of the compounds from Phryma leptostachya L.

Authors 

Sang Myung LeeByung Sun MinYung Hee Kho

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2002

Citation 

Archives of Pharmacal Research, vol. 25, no. 5, pp. 652-654

Keywords 

brine shrimpcytotoxicityphryma leptostachya L.phrymarolin IIursolic acidplant extractanimalcell cultureisolation and purificationmedicinal plant

Abstract 

Brine shrimp assay-guided fractionation and isolation of the EtOAc soluble fraction of Phryma leptostachya L. (Phrymacaceae) gave two active compounds, phrymarolin II (1) and ursolic acid (2), which were identified by physicochemical and spectroscopic methods. Compound 1 exhibited potent lethality with LD50 value of 0.0013 μg/ml, whereas 2 showed moderate lethality with LD50 value of 27.0 μg/ml against brine shrimp. The cytotoxic activities of 1 and 2 were also evaluated against one murine and five human cancer cell lines employing the sulforhodamin B (SRB) method. Compound 2 exhibited cytotoxic activity against L1210 and SK-MEL-2 cells with ED 50 values of 3.70 and 9.27 mg/ml, respectively, whereas 1 was devoid of any cytotoxic activity against all cancer cells tested.

ISSN 

0253-6269

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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