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Title | Benzastatin J, a new demethylated derivative of benzastatin B produced by controlled fermentation of Streptomyces nitrosporeus |
Authors | Won Gon Kim; Ick Dong Yoo |
Publisher | The Korean Society for Applied Microbiology |
Issue Date | 2002 |
Citation | Journal of Microbiology and Biotechnology, vol. 12, no. 5, pp. 838-840 |
Keywords | benzastatin; demethylation; p-aminobenzoic acid; streptomyces nitrosporeus; supplementation; 4 aminobenzamide; 4 aminobenzoic acid; benzamide derivative; glutamic acid; idebenone |
Abstract | Feeding experiments of various derivatives of p-aminobenzamide to benzastatins-producing Streptomyces nitrosporeus were performed to observe whether new biosynthetic analogs of benzastatins were produced. The supplementation of p-aminobenzoic acid to the culture medium of Streptomyces nitrosporeus led to the production of benzastatin J, a new demethylated derivative of benzastatin B, while production of benzastatins A and B increased and benzastatins C-G were not detected. |
ISSN | 1017-7825 |
Appears in Collections | |
Registered Date |
2019-05-02 |
