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Title 

Anti-human immunodeficiency virus-type 1 activity of constituents from Juglans mandshurica

Authors 

Byung Sun MinHyeong Kyu LeeSang Myung LeeYoung Ho KimK H BaeT OtakeN NakamuraM Hattori

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2002

Citation 

Archives of Pharmacal Research, vol. 25, no. 4, pp. 441-445

Keywords 

anti-HIV activityjuglans mandshuricaMT-4 cellstaxifolinanti human immunodeficiency virus agenthumanhuman immunodeficiency virus 1anti-HIV agentsHIV-1humans

Abstract 

Three naphthalene glycosides (1-3), four flavonoids (4-7), and two galloyl glycosides (8-9) were isolated from the stem-bark of Juglans mandshurica (Juglandaceae). Their structures were determined by chemical and spectral means, including to 2D-NMR (COSY, HMQC, and HMBC) experiments. Amongst the isolated compounds, taxifolin (4) showed the most potent HIV-induced cytopethic activity against MT-4 cells with complete inhibitory concentration (IC100) value of 25 μg/ml and maximum cytotoxic concentration (CC100) value of above 100 μg/ml. However, naphthalene glycosides (1-3), flavonoids (5-7)), and galloyl tannins (8-9) were inactive against anti-HIV-1 activity.

ISSN 

0253-6269

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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