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Title 

Cytotoxicity of lignans from Lindera erytherocarpa makino

Authors 

Sang Myung LeeSeung Hwa BaekChoong Hwan LeeHyang Burm LeeYung Hee Kho

Publisher 

Korean Society of Pharmacognosy

Issue Date 

2002

Citation 

Natural Products Sciences, vol. 8, no. 3, pp. 100-102

Keywords 

cytotoxicitykanakugiollindera erytherocarpa Mak.linderonemethyllinderonelindera erytherocarpa

Abstract 

Three lignans were isolated from a methanol extract of Lindera erytherocarpa Makino (Lauraceae) are evaluated in vitro cytotoxicity using three cancer cell line assay. The compounds were identified as methyllinderone (1), linderone (2), and kanakugiol (3) by spectroscopic methods. Amongst the compounds, methyllinderone (1) showed significant cytotoxicity against mouse melanoma (B16-F10), human acetabulum fibrosarcoma (HT1080), and choronic myelogenous leukemia (K562) cancer cell lines with ED50 values of 2.2, 2.5, 8.3 μg/ml, respectively.

ISSN 

1226-3907

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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