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Title 

Plasma cell granuloma in cyclosporine-induced gingival overgrowth : a report of two cases with immunohistochemical positivity of interleukin-6 and phospholipase C-γ1

Authors 

S S KimD W EomJ R HuhL Y SungIn Pyo ChoiS H RyuP G SuhS M Chung

Publisher 

Korean Academy of Medical Sciences

Issue Date 

2002

Citation 

Journal of Korean Medical Science, vol. 17, no. 5, pp. 704-707

Keywords 

immunosuppressive agentphospholipase Cphospholipase C gammacase reportchemically induced disorderfemalegingiva diseasehumankidney transplantationmalemetabolism

Abstract 

We report two cases of gingival plasma cell granuloma in a 34-yr-old and 40-yr-old two male renal transplant recipients with cyclosporine A (CsA)-induced gingival overgrowth (GO). Histologically, these lesions were composed of mature plasma cells, showing polyclonality for both lambda and kappa light chains and fibrovascular connective tissue stroma. In addition to the fact that CsA-induced plasma cell granuloma is rare, the salient features of our cases were the secretion of interleukin-6 and overexpression of phospholipase C- gamma 1 of the tumor cells, which may explain the mechanisms of CsA- induced GO.

ISSN 

1011-8934

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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