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Title 

Inhibition of VHR dual-specificity protein tyrosine phosphatase activity by flavonoids isolated from Scutellaria baicalensis: structure-activity relationships

Authors 

myung sun LeeWon Keun OhBo Yeon KimSoon Cheol AhnDae Ook KangC B SohnH OsadaJong Seog Ahn

Publisher 

Georg Thieme Verlag

Issue Date 

2002

Citation 

Planta Medica, vol. 68, no. 12, pp. 1063-1065

Keywords 

flavonoidphosphoprotein phosphatase 1phosphoprotein phosphatase inhibitorprotein tyrosine phosphatasescutellaria baicalensis extractserine threonine protein phosphatase 1virus proteindrug structureenzyme activityenzyme inhibition

Abstract 

Three flavonoids: norwogonin, dihydronorwogonin and baicalein, were isolated from the roots of Scutellaria baicalensis, as potential inhibitors of VHR dual-specificity protein tyrosine phosphatase (DS-PTPase). Norwogonin (IC50 = 1.1μM), dihydronorwogonin (IC50 = 2.9μM) and baicalein (IC50 = 2.4μM) showed potent inhibitory activity toward VHR, but had no inhibitory activity against T-cell protein tyrosine phosphatase or serine/threonine protein phosphatase 1. From comparisons to the inhibitory activities of other similar flavonoids, it could be suggested that the presence of a hydroxy group in the B ring of flavonoids interferes with the inhibitory activity toward VHR DS-PTPase.

ISSN 

0032-0943

Link 

http://dx.doi.org/10.1055/s-2002-36351

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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