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Title 

Quinolone alkaloids, diacylglycerol acyltransferase inhibitors from the fruits of Evodia rutaecarpa

Authors 

Jeong Suk KoMun Chual RhoMi Yeon ChungHye Young SongJ S KangKoan Hoi KimHyun Sun LeeYoung Kook Kim

Publisher 

Georg Thieme Verlag

Issue Date 

2002

Citation 

Planta Medica, vol. 68, no. 12, pp. 1131-1133

Keywords 

1 methyl 2 (4,7 decadienyl) 4 quinolone1 methyl 2 (6,9 pentadecadienyl) 4 quinolone1 methyl 2 tetradecyl 4 quinolonealkaloiddiacylglycerol acyltransferase inhibitorenzyme inhibitorquinolone derivativeevodia rutaecarpafruitacyltransferases

Abstract 

From the diacylglycerol acyltransferase (DGAT) activity-guided fractionation, a new quinolone alkaloid, 1-methyl-2-tetradecyl-4(1H)-quinolone (1) was isolated from the fruits of Evodia rutaecarpa together with three known quinolone alkaloids, evocarpine (2), 1-methyl-2-[(4Z,7Z)-4,7-decadienyl]-4(1H)-quinolone (3) and 1-methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone (4). They showed a dose-dependent DGAT inhibition with IC50 values of 69.5 μM (1), 23.8 μM (2), 20.1 μM (3) and 13.5 μ (4).

ISSN 

0032-0943

Link 

http://dx.doi.org/10.1055/s-2002-36358

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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